Document Type
Thesis
Date of Award
8-2022
School/College
College of Science, Engineering, and Technology (COSET)
Degree Name
MS in Biology
Committee Chairperson
Alamelu Sundaresan
Committee Member 1
Sodipe Ayodotun
Committee Member 2
Olufemi Shodimmu
Committee Member 3
Wilkerson Daryl
Keywords
ETAS, Heat Shock Protein Complex, Heat Shock Proteins, HSP70, Oxidative Stress
Abstract
Neurodegenerative disease in the CNS is usually a product of increased oxidative stress in the brain. In this study we tested the ability of an asparagus supplement ETAS to help reduce oxidative stress in the normal brains of Balb C mice. Oxidative stress pathways (Heat shock proteins) are usually cumulative in the damage they cause when disrupted. We treated normal Balb C mice with ETAS and had control groups with no ETAS supplementation in their regular diet. We then sacrificed the mice and conducted microarray studies to compare oxidative stress pathway genes. We also characterized the effects of regular oxidative cells in a mammalian cell model treated with alcohol to understand how oxidative stress impairs the functions of a normal neuronal cell. Results from both in vivo and in vitro experiments will be described in this study.
Copyright
Copyright © for this work is retained by the author. Any documents and information presented are protected by copyright under US Copyright laws and are the property of the author. All Rights Reserved. For permission to use this content please contact the author or the Graduate School at Texas Southern University (graduate.school@tsu.edu).
Recommended Citation
Carter, Taylor, "HSP- 70 Mediated Nervous System Enhancement by ETAS" (2022). Theses (2016-Present). 4.
https://digitalscholarship.tsu.edu/theses/4