Keegan Smiley

Document Type

Thesis

Date of Award

5-2007

School/College

College of Science, Engineering, and Technology (COSET)

Degree Name

MS in Biology

First Advisor

G. Ramesh

Abstract

Although micro gravity means tiny or reduced gravity, it is a term frequently 􁪽􁪽., applied to label a state of free-fall within a gravitational field in which a comparison is made between the decreasing weight of an object and its stationary weight on Earth. The cardiovascular system undergoes several adaptations during spaceflight as the effects of microgravity allow fluids inside the body to redistribute. This activity is known as a "fluid shift" and is distinguished by a shift in the flow of blood and fluids toward the head. The results of this "fluid shift" are visible in astronauts exhibiting a "puffy, swelled-up" heads and thinner legs. It is a well known fact that microgravity induces oxidative stress and causes severe damage to various tissues and organ systems. Though extensive studies were carried out on the effect of microgravity on immune functions, very little is known about its effect on biochemical functions of cardiovascular system. Hence in our study we analyze the effect of micro gravity on stress induced parameters, such as lipid peroxide, Glutathione and enzymes Lactate dehydrogenase, Glutathione Peroxidase, Catalase, Dismutase etc. These enzymes are very important in coordinating and regulating the metabolic functions. Needless to say, the disruption many of these enzymes present in 2 cardiovascular system could cause serious damage to the cells. We use in our studies the most popular ground based rodent model the hind limb suspension (HLS model) to simulate the microgravity. In this HLS model the mice are suspended by the tail base to produce 30-degree head down position. This study will give insights into the effect of micro gravity on heart functions and may ,.,. , help to develop the counter measures for the safe journey for astronauts.

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