Honor’s College Freeman Research Journal

Author

Aubri Ford

Date of Award

Spring 5-2022

Document Type

Thesis

Department

Biology

First Advisor

Dr. Ayodotun Sodipe

Abstract

Respiration is an essential part of life. The diaphragm is the main muscle involved in the process of respiration. However, respiratory diseases such as emphysema alter the function of the diaphragm which sometimes leads to respiratory failure and death. This review compiles studies concerning emphysema and how the morphological changes in the lungs (i.e. hyperinflation) caused by the disease affect the diaphragm. The first major point covers the risks associated with developing the disease as a component of Chronic Obstructive Pulmonary Disease (COPD). Next, the paper outlines the pathophysiology of emphysema within the lungs, the methods used to diagnose emphysema, and different therapies implemented to alleviate many of the complications associated with the disease. Finally, the paper explores how emphysema can induce changes in the function of the diaphragm through a systematic journal review. The goal of this paper is to elucidate the ways in which hyperinflation of the lungs caused by emphysema alters the mechanics of the diaphragm.

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