Sajina Poudel

Document Type


Date of Award



College of Science, Engineering, and Technology (COSET)

Degree Name

MS in Biology

Committee Chairperson

Alamelu Sundaresan

Committee Member 1

Hector Miranda

Committee Member 2

Ayodotun Sodipe

Committee Member 3

Daryl Wilkerson


AHCC (Active Hexose Correlated Compounds), B lymphocytes, Genes, Immunity, T lymphocytes


AHCC is a beta-glucan derived from the shiitake mushroom. It is used as an immune supplement and is known to boost the immune system. The mechanisms involved are increased lymphocyte proliferation and reduction of inflammation. The effects have been well studied in T cells. However, factors produced by T cells that affect B cells have not been studied. In this study, we explored the gene products stimulated by the AHCC exposure in T lymphocytes which play a role in B cell function. Data from a prior gene array experiment were used to delineate the effects of AHCC on the interaction between T and B lymphocytes.