Date of Award
College of Science, Engineering, and Technology (COSET)
MS in Chemistry
Dr. B. John Sapp
Platinum and Ruthenium complexes show prospective as an antitumor and antimetastasis agent. The lower toxicity found with ruthenium compared to platinum and the advantages of ruthenium's geometric shape made it more advantageous for my antitumor research. Reaction of metal-metal bonded complex diruthenium tetraacetate chloride (RU2(02CCH3)4Cl and ethyl-4-[(pyridine-3-yl) amino] benzoate leads to the synthesis of diruthenium tetraethyl-4-[(pyridine-3-yl) amino] benzoate chloride. The complex was examined using infrared spectroscopy and thermal gravitational analysis. The infrared spectroscopy allowed comparison with original compound and synthesized complexes to see new bonds and functional groups that were formed, which helped in identifying the formation of ethyl-4-[(pyridine-3-yl) amino] benzoate. Thermal gravimetric analysis indicates that the complex synthesized had two ruthenium atoms. It also helped determine that four ethyl-4-[(pyridine-3-yl) amino] benzoate were bonded to 1 2 two ruthenium's which were originally attached to four acetate chloride's. Similarities with functional group's (such as the NH2, Cl and arene groups) within the synthesized diruthenium complex and ruthenium complexes which are currently being researched and/ or in clinical trial stages show antitumor and antimetatasis potential in the synthesized complex
Echeruo, Uzoma Chidimma, "The Synthesis and Characterization of a Diruthenium Complexe-diruthenium Tetra ETHYL-4-[(PYRIDIN-3-YL] AMINO) Benzoate Chloride- A Potential Chemotherapeutic Agent." (2012). Theses (Pre-2016). 234.