Document Type


Date of Award



College of Pharmacy and Health Sciences (COPHS)

Degree Name

MS Pharmaceutical Science

First Advisor

Professor Adebayo Oyekan


Peroxisome Proliferator-Activated Receptor alpha (PPARa) is known to exert many cardiorenal protective effects. In contrast, T- helper cell 17 (ThI7) and scavenger receptor CD36 have been implicated in hypertension (HTN) and Inflammation. In addition, PPARa has been found to promote CD36 function. We hypothesized that PPARa exerts anti-inflammatory effect by inhibiting CD36-induced Th17 proliferation and differentiation in the kidney in Angiotensin II (AngII)-induced renal injury. The aim of this study is to evaluate the role of PPARa in amelioration of hypertensive renal injury due to CD36-mediated Th17 activation in HTN. In animals treated with WY14643, a PPARa agonist, or GW64 71, a PPARa antagonist, no significant difference in blood pressure (BP) was found between control and Ang II animals. However, GW6471 increased BP (188 ± 23 Vs 154 ± 9 mmHg; P